“When we think along Biblical lines and the term “two by two” comes up it is natural to think of Noah and the animals, going into the ark two by two. “But going even further back what about the creation story. God created man and woman even to be two in one.” “Two in one flesh, is intended to be even more intimate than two side by side.”
Jesus began to send the Twelve out two by two and gave them authority over the unclean spirits. Mark 6:7-13.
Pope Francis. Whenever we encounter another person in love we learn something new about God. EG272